Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage.
Kontogianni K., Bengey D., Wooding D., Buist K., Greenland-Bews C., Williams CT., Vos MD., Santos VS., Escadafal C., Adams ER., Edwards T., Cubas-Atienzar AI.
BackgroundThe emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant.MethodsAg-RDTs were performed according to the manufacturer's instructions with a clinical isolate of the Gamma variant.ResultsTwenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria.ConclusionsThis comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC.