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Louise Sigfrid

Louise Sigfrid

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Aim: to study the prevalence, clinical management and outcomes of endemic arboviruses in Southeast Europe, focusing on West Nile Virus (WNV), tick-borne encephalitis virus (TBEV), Toscana virus (TOSV) and Crimean Congo haemorrhagic fever virus (CCHFV) (2016-2019).

Websites

Louise Sigfrid

MD, PhD, FFPH

Senior Clinical Research Fellow

  • Senior Researcher Pandemic PACT
  • Honorary Academic Public Health Consultant, UK Health Security Agency

Work and Interests

Louise main focus is to strengthen preparedness for coordinated, effective research responses to epidemics and pandemics, to reduce morbidity and improve outcomes through clinical research, capacity strengthening and policy work. Further, with a focus and passion for reducing health inequalities and inequity in all aspects of work.

Louise research focus includes observational clinical, public health and social studies with a focus on new and (re-) emerging infections with epidemic potential, including acute respiratory infections (ARI), central nervous system (CNS), arbovirus and viral haemorrhagic fever (VHF) syndromes. She is managing a project exploring availability, inclusivity, scope and quality of clinical management guidelines (CMGs) for high consequence infectious diseases (HCIDs), and factors impacting on implementation of Chikungunya guidelines in Indonesia, and VHF guidelines in West Africa.

Louise is leading the Rapid Research Needs Appraisal Project and Team within Pandemic PACT, with a mission to establish a baseline of evidence for Priority Diseases of Public Health Concern, to identify gaps in the evidence base across a range of research domain categories (clinical characteristics, transmission, immune response, medical countermeasures and associated social and behavioural aspects) across demographics, to inform clinical, public health management and research prioritisation to generate new evidence to protect populations and improve outcomes.

As part of her work supporting ISARICs mission, Louise co-lead the development of COVID-19 follow up protocol in collaboration with multidisciplinary stakeholders and people living with Long Covid in 2020. These have been implemented in sites globally characterising risk of and risk factors for Long Covid in different populations and settings. She co-chaired the ISARIC Global Covid-19 Follow Up working groups for adults and children, bringing international scientists, clinicians and patient group representatives together to characterise long term SARS-CoV-2 outcomes in different populations, with an aim to improve long term Covid-19 outcomes through research, engagement and advocacy.

She supports capacity and workforce development through teaching, supervision and outbreak response exercises.