Sophie Yacoub
Professor of Infectious Diseases
Sophie is a Professor of Infectious Diseases at the Pandemic Sciences Institute, University of Oxford. She is a Wellcome Trust Clinical Career Development Fellow and Physician in Infectious Diseases and General Medicine. She holds an honorary consultant appointment at London North West University Healthcare NHS Trust in the UK. She has a PhD from Imperial College London and an MSc from the London School of Hygiene and Tropical Medicine. She is a member of the Royal College of Physicians in London.
Sophie has >12 years experience in clinical research into dengue in South East Asia. During her time in OUCRU-Vietnam she set up a large translational programme of dengue research, focusing on clinical trials, pathogenesis studies and innovative technology centered on wearable devices, physiological monitoring and utilizing AI for medical imaging and clinical decision support systems. Her work has been supported from funding through Wellcome, UKRI, Academy of Medical sciences, LifeArc, Singapore NMRC and the WHO.
She is now leading an antiviral platform trial for early dengue infections (ADAPT) and is setting up a global platform trial across 10 countries to investigate multiple therapeutics for patients hospitalized with dengue.
Key publications
Core outcome measurement set for clinical trials in dengue: an international Delphi consensus study (DEN-CORE)
Journal article
Yacoub S. et al, (2026), The Lancet Infectious Diseases, 26, e231 - e244
Safety and tolerability of metformin in overweight and obese patients with dengue: An open-label clinical trial (MeDO)
Journal article
Minh Nguyen N. et al, (2025), PLOS Neglected Tropical Diseases, 19, e0013281 - e0013281
The Diagnosis of Dengue in Patients Presenting With Acute Febrile Illness Using Supervised Machine Learning and Impact of Seasonality.
Journal article
Ming DK. et al, (2022), Frontiers in digital health, 4
Digital and technological innovation in vector-borne disease surveillance to predict, detect, and control climate-driven outbreaks.
Journal article
Pley C. et al, (2021), The Lancet. Planetary health, 5, e739 - e745
Targeting hyperinflammation in infection: can we harness the COVID-19 therapeutics momentum to end the dengue drugs drought?
Journal article
McBride A. et al, (2021), The Lancet Microbe, 2, e277 - e278
Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes
Journal article
Vuong NL. et al, (2021), eLife, 10
Higher Plasma Viremia in the Febrile Phase Is Associated With Adverse Dengue Outcomes Irrespective of Infecting Serotype or Host Immune Status: An Analysis of 5642 Vietnamese Cases
Journal article
Vuong NL. et al, (2021), Clinical Infectious Diseases, 72, e1074 - e1083
THE COMPENSATORY RESERVE INDEX FOR PREDICTING SHOCK IN INTENSIVE CARE PATIENTS WITH SEVERE DENGUE
Conference paper
Huynh TT. et al, (2019), AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 101, 2 - 3
Cardiovascular manifestations of the emerging dengue pandemic
Journal article
Yacoub S. et al, (2014), Nature Reviews Cardiology, 11, 335 - 345
Recent publications
The Case for N-acetylcysteine in Dengue Associated Liver Injury: Time for Definitive Evidence
Journal article
McBride A. et al, (2026), Open Forum Infectious Diseases, 13
A systematic mapping review of therapeutic clinical trials in dengue
Journal article
Huyen TB. et al, (2026), PLOS Neglected Tropical Diseases, 20, e0014382 - e0014382
Integrated validation of internally controlled one-step multiplex real-time RT-PCR for dengue virus serotyping and monoplex assay for quantification.
Journal article
Thuy LTP. et al, (2026), Journal of virological methods, 343
The cost of dengue shock and septic shock in Vietnam: a patient-centred economic analysis
Journal article
McBride A. et al, (2026), International Health, 18, 431 - 439
Core outcome measurement set for clinical trials in dengue: an international Delphi consensus study (DEN-CORE)
Journal article
Yacoub S. et al, (2026), The Lancet Infectious Diseases, 26, e231 - e244
Serial bedside echocardiography identifies children at risk of recurrent Dengue shock: a prospective cohort study
Journal article
Chanh HQ. et al, (2026), BMC Emergency Medicine, 26
Early individualized risk prediction using clinical data for children during the febrile phase of dengue in outpatient settings in Vietnam and Thailand.
Journal article
Sangkaew S. et al, (2026), PLOS digital health, 5
Dengue therapeutics consortium 2025: a global collaboration in action
Journal article
McBride A. et al, (2026), BMJ Public Health, 4, e004043 - e004043