Julio Diaz
Senior Bioinformatician
Julio is a bioinformatician with a focus on bacterial genomics, evolutionary biology, and big data. He obtained his PhD from the Department of Cell and Systems Biology at the University of Toronto. During his PhD, Julio worked to be better understand the within-patient evolution of infectious bacterial populations in cystic fibrosis lungs. Here, he combined deep sampling and next generation sequencing with bioinformatics and statistical methods to identify changes in the bacterial population diversity that could be associated with the clinical history of the patient. After his PhD, Julio joined the Zoology department at the University of Oxford to study bacterial infections in intensive care units across Europe.
Julio joined CGPS in November 2021 to work on the AMRwatch project. In this project, he leads the implementation of bioinformatics tools and the development of supporting material for the assembly and analysis of all the genomes of organisms in the WHO pathogen priority list. He is also interested in training fellow researchers in bioinformatics and bacterial genomics
Recent publications
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Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient.
Journal article
Wheatley RM. et al, (2022), Nature communications, 13
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Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic
Journal article
Jangir PK. et al, (2022), eLife, 11
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Localized pmrB hypermutation drives the evolution of colistin heteroresistance.
Journal article
Kapel N. et al, (2022), Cell reports, 39
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Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection
Journal article
Wheatley R. et al, (2021), Nature Communications, 12
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Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex.
Journal article
Rizzolo K. et al, (2021), Nature communications, 12