Mahan Gafari
Postdoctoral Research Scientist
I am mainly interested in understanding the evolutionary and epidemiological processes involved in determining the rate at which viruses evolve over time. In my current postdoctoral work, I study the within-host evolutionary dynamics, and transmission, of chronic viral infections such as SARS-CoV-2 and HIV. My focus is on analysing whole genome sequencing data to better understand the within-host evolution and transmission of these viruses, including the roles of selection, recombination, and compartmentalisation.
Recent publications
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The evolution of SARS-CoV-2.
Journal article
Markov PV. et al, (2023), Nat Rev Microbiol
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Estimating SARS-CoV-2 variant fitness and the impact of interventions in England using statistical and geo-spatial agent-based models.
Journal article
Hinch R. et al, (2022), Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 380
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A framework for reconstructing SARS-CoV-2 transmission dynamics using excess mortality data.
Journal article
Ghafari M. et al, (2022), Nature communications, 13
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Purifying Selection Determines the Short-Term Time Dependency of Evolutionary Rates in SARS-CoV-2 and pH1N1 Influenza
Journal article
Ghafari M. et al, (2022), Molecular Biology and Evolution, 39
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A mechanistic evolutionary model explains the time-dependent pattern of substitution rates in viruses.
Journal article
Ghafari M. et al, (2021), Current biology : CB, 31, 4689 - 4696.e5