Director of the Research and Development Institute
Carroll Group: High Consequence Emerging Viruses Group
HOST-PATHOGEN INTERACTIONS OF HIGH CONSEQUENCE EMERGING VIRUSES
Our work centres around high consequence emerging viral infections. Currently, our focus is on Ebola, Lassa fever and SARS-CoV-2. We are interested in host-pathogen interactions, development of anti-virals and recently we have been looking at the IgG response following SARS-CoV-2 infection and/or vaccination in humans and animal models. To further support this work we are using a live virus neutralisation, multiplex immunoassays and novel ACE2 inhibition assay to inform on the ability of serum to neutralise SARS-CoV-2 variants of concern (VOC). We are also interested in the innate response to viral infection, particularly activation and/or evasion of the complement system
Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes.
Dong X. et al, (2023), Microbiol Spectr
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens.
Moore SC. et al, (2023), Med (N Y)
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine
Brewitz L. et al, (2023), Journal of Medicinal Chemistry
Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea
Longet S. et al, (2023), Emerging Infectious Diseases, 29, 304 - 313
Pre-clinical models to define correlates of protection for SARS-CoV-2.
Brady C. et al, (2023), Frontiers in immunology, 14