Sophie Yacoub
Associate Professor of Infectious Diseases
Sophie is an Associate Professor of Infectious Diseases at the Pandemic Sciences Institute, University of Oxford. She is a Wellcome Trust Clinical Career Development Fellow and Physician in Infectious Diseases and General Medicine. She holds an honorary consultant appointment at London North West University Healthcare NHS Trust in the UK. She has a PhD from Imperial College London and an MSc from the London School of Hygiene and Tropical Medicine. She is a member of the Royal College of Physicians in London.
Sophie has >12 years experience in clinical research into dengue in South East Asia. During her time in OUCRU-Vietnam she set up a large translational programme of dengue research, focusing on clinical trials, pathogenesis studies and innovative technology centered on wearable devices, physiological monitoring and utilizing AI for medical imaging and clinical decision support systems. Her work has been supported from funding through Wellcome, UKRI, Academy of Medical sciences, LifeArc, Singapore NMRC and the WHO.
She is now leading an antiviral platform trial for early dengue infections (ADAPT) and is setting up a global platform trial across 10 countries to investigate multiple therapeutics for patients hospitalized with dengue.
Key publications
-
Automatic Retrieval of Corresponding US Views in Longitudinal Examinations
Conference paper
Kerdegari H. et al, (2023), MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION, MICCAI 2023, PT I, 14220, 152 - 161
-
Targeting hyperinflammation in infection: can we harness the COVID-19 therapeutics momentum to end the dengue drugs drought?
Journal article
McBride A. et al, (2021), The Lancet Microbe, 2, e277 - e278
-
Automatic Detection of B-lines in Lung Ultrasound Videos from Severe Dengue Patients
Conference paper
Kerdegari H. et al, (2021), 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), 989 - 993
-
Microvascular and endothelial function for risk prediction in dengue: an observational study
Journal article
Yacoub S. et al, (2015), The Lancet, 385, S102 - S102
-
Visual and Biochemical Evidence of Glycocalyx Disruption in Human Dengue Infection, and Association With Plasma Leakage Severity
Journal article
Lam PK. et al, (2020), Frontiers in Medicine, 7
-
Higher Plasma Viremia in the Febrile Phase Is Associated With Adverse Dengue Outcomes Irrespective of Infecting Serotype or Host Immune Status: An Analysis of 5642 Vietnamese Cases
Journal article
Vuong NL. et al, (2021), Clinical Infectious Diseases, 72, e1074 - e1083
-
The influence of fluid resuscitation strategy on outcomes from dengue shock syndrome: a review of the management of 691 children in 7 Southeast Asian hospitals.
Journal article
Trieu HT. et al, (2025), BMJ global health, 10
-
Transaminases and serum albumin as early predictors of severe dengue - Authors' reply.
Journal article
Sangkaew S. et al, (2021), The Lancet. Infectious diseases, 21, 1489 - 1490
-
Definitions for warning signs and signs of severe dengue according to the WHO 2009 classification: Systematic review of literature
Journal article
Morra ME. et al, (2018), Reviews in Medical Virology, 28
Recent publications
-
The cost of dengue shock and septic shock in Vietnam: a patient-centred economic analysis.
Journal article
McBride A. et al, (2025), International health
-
Safety and tolerability of metformin in overweight and obese patients with dengue: An open-label clinical trial (MeDO)
Journal article
Minh Nguyen N. et al, (2025), PLOS Neglected Tropical Diseases, 19, e0013281 - e0013281
-
The influence of fluid resuscitation strategy on outcomes from dengue shock syndrome: a review of the management of 691 children in 7 Southeast Asian hospitals.
Journal article
Trieu HT. et al, (2025), BMJ global health, 10
-
Status of Digital Health Technology Adoption in 5 Vietnamese Hospitals: Cross-Sectional Assessment
Journal article
Tran DM. et al, (2025), JMIR Formative Research, 9, e53483 - e53483
-
Anakinra for dengue patients with hyperinflammation: protocol for a randomized double-blind placebo-controlled trial
Journal article
Huyen TB. et al, (2024), Wellcome Open Research, 9, 689 - 689