The Case for N-acetylcysteine in Dengue Associated Liver Injury: Time for Definitive Evidence
McBride A., Vuong NL., Adhikari S., Han SM., Chia PY., Trieu HT., Lam PK., Chanh HQ., Rajahram G., Horby P., Yeo TW., Kestelyn E., Watson J., Trung TN., Yacoub S.
Abstract Dengue-associated liver injury is common, prognostically significant, and associated with high mortality at severe thresholds. Oxidative stress is a key, potentially modifiable mechanism. N-acetylcysteine has strong biological plausibility and supportive preclinical data, but clinical evidence remains limited, underscoring the need for well-designed randomized trials to inform practice and policy.