Integrating epidemiological and genetic data with different sampling intensities into a dynamic model of respiratory syncytial virus transmission.
Kombe IK., Agoti CN., Munywoki PK., Baguelin M., Nokes DJ., Medley GF.
Respiratory syncytial virus (RSV) is responsible for a significant burden of severe acute lower respiratory tract illness in children under 5 years old; particularly infants. Prior to rolling out any vaccination program, identification of the source of infant infections could further guide vaccination strategies. We extended a dynamic model calibrated at the individual host level initially fit to social-temporal data on shedding patterns to include whole genome sequencing data available at a lower sampling intensity. The study population was 493 individuals (55 aged