Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

Brewitz L., Dumjahn L., Zhao Y., Owen CD., Laidlaw SM., Malla TR., Nguyen D., Lukacik P., Salah E., Crawshaw AD., Warren AJ., Trincao J., Strain-Damerell C., Carroll MW., Walsh MA., Schofield CJ.

DOI

10.1021/acs.jmedchem.2c01627

Type

Journal article

Journal

Journal of Medicinal Chemistry

Publisher

American Chemical Society (ACS)

Publication Date

09/02/2023

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