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ABSTRACT A human immunodeficiency virus type 1 (HIV-1) vaccine that induces potent immune responses in the gastrointestinal mucosa would be highly desirable. Here we show that attenuated recombinant Listeria monocytogenes , administered orally utilizing its natural route of infection, induces potent mucosal as well as systemic immune responses in mice. Moreover, these responses can be boosted efficiently with replication-incompetent adenoviral vectors. L. monocytogenes elicited more potent simian immunodeficiency virus (SIV) Gag-specific CD8 + T lymphocyte responses in mucosal compartments than DNA vaccines.

Original publication

DOI

10.1128/jvi.03085-12

Type

Journal article

Journal

Journal of Virology

Publisher

American Society for Microbiology

Publication Date

15/04/2013

Volume

87

Pages

4751 - 4755