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Structural basis of Norrin recognition by Lgr4/5/6

Preprint

Chang T-H. et al, (2022)

Structural Analysis and Development of Notum Fragment Screening Hits.

Journal article

Zhao Y. et al, (2022), ACS chemical neuroscience

The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs.

Journal article

Jackson V. et al, (2022), Structure (London, England : 1993)

Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status

Journal article

Eyre DW. et al, (2021), Clinical Microbiology and Infection, 27, 1516.e7 - 1516.e14

Structural Insights into Notum Covalent Inhibition

Journal article

Zhao Y. et al, (2021), Journal of Medicinal Chemistry, 64, 11354 - 11363

Notum deacylates octanoylated ghrelin

Journal article

Zhao Y. et al, (2021), Molecular Metabolism, 49, 101201 - 101201

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Journal article

Flanagan DJ. et al, (2021), Nature, 594, 430 - 435

Small-molecule inhibitors of carboxylesterase Notum

Journal article

Zhao Y. et al, (2021), Future Medicinal Chemistry, 13, 1001 - 1015

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Journal article

Schwerd T. et al, (2020), Bone Research, 8

Caffeine inhibits Notum activity by binding at the catalytic pocket

Journal article

Zhao Y. et al, (2020), Communications Biology, 3

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

Journal article

Zhao Y. et al, (2020), Nature Communications, 11

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.

Journal article

Bochel AJ. et al, (2020), Structure (London, England : 1993), 28, 1300 - 1312.e5

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

Journal article

McGough IJ. et al, (2020), Nature, 585, 85 - 90

Structural basis of semaphorin‐plexin cis interaction

Journal article

Rozbesky D. et al, (2020), The EMBO Journal, 39

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.

Journal article

Schwerd T. et al, (2020), Bone research, 8

Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility

Journal article

Rozbesky D. et al, (2020), Structure, 28, 507 - 515.e5

Cell guidance ligands, receptors and complexes - orchestrating signalling in time and space.

Journal article

Rozbesky D. and Jones EY., (2020), Current opinion in structural biology, 61, 79 - 85

Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

Journal article

Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260

Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum

Journal article

Zhao Y. et al, (2020), Journal of Pineal Research, 68

The guidance receptor plexin D1 is a mechanosensor in endothelial cells.

Journal article

Mehta V. et al, (2020), Nature, 578, 290 - 295

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.

Journal article

Atkinson BN. et al, (2020), Bioorganic & medicinal chemistry letters, 30

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Journal article

Rozbesky D. et al, (2019), Nature Communications, 10

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Journal article

Chen S. et al, (2019), Proceedings of the National Academy of Sciences, 116, 17470 - 17479

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

Journal article

van der Klaauw AA. et al, (2019), Cell, 176, 729 - 742.e18

Designer protein delivers signal of choice

Journal article

Jones EY., (2019), Nature, 565, 165 - 166

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins

Journal article

Elegheert J. et al, (2018), Nature Protocols, 13, 2991 - 3017

Structure of the Wnt signaling enhancer LYPD 6 and its interactions with the Wnt coreceptor LRP 6

Journal article

Zhao Y. et al, (2018), FEBS Letters, 592, 3152 - 3162

Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function

Journal article

Chavent M. et al, (2018), Structure, 26, 1025 - 1034.e2

Structural biology and the molecular mechanics of cell guidance signalling

Conference paper

Jones EY., (2018), FEBS OPEN BIO, 8, 57 - 57

A Calcium-Sensing Receptor (CASR) Mutation Causes Hypocalcemia by Disrupting a Transmembrane Salt Bridge that Modulates beta-arrestin Signaling.

Conference paper

Gorvin C. et al, (2017), JOURNAL OF BONE AND MINERAL RESEARCH, 32, S133 - S133

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

Journal article

Schwerd T. et al, (2017), Journal of Experimental Medicine, 214, 2547 - 2562

Notum - an extracellular protein deacylase that suppresses Wnt signalling

Conference paper

Jones EY. et al, (2017), ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 73, C260 - C260

Structure of Functional Neuropilin-Centred Class 3 Semaphorin and VEGF Receptors

Chapter

Jones EY., (2017), The Neuropilins: Role and Function in Health and Disease, 9 - 21

Structural Perspectives on Axon Guidance

Journal article

Seiradake E. et al, (2016), Annual Review of Cell and Developmental Biology, 32, 577 - 608

Structural Basis for Plexin Activation and Regulation

Journal article

Kong Y. et al, (2016), Neuron, 91, 548 - 560

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