Publications

Structural insights into Frizzled3 through nanobody modulators.

Hillier J. et al, (2024), Nat Commun, 15

Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification

Pouwels KB. et al, (2024), Nature Communications, 15

Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain

Powell GT. et al, (2024), Science, 384, 573 - 579

Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.

Barnkob MB. et al, (2024), Nat Commun, 15

Structure and function of Semaphorin-5A glycosaminoglycan interactions

Nagy GN. et al, (2024), Nature Communications, 15

Structural basis of Norrin recognition by Lgr4/5/6

Chang T-H. et al, (2022)

Structural insights into Frizzled assembly by acylated Wnt and Frizzled Connector domain

Chang T-H. et al, (2022)

Structural Analysis and Development of Notum Fragment Screening Hits.

Zhao Y. et al, (2022), ACS chemical neuroscience

The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs.

Jackson V. et al, (2022), Structure (London, England : 1993)

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

Powell GT. et al, (2022)

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Willis NJ. et al, (2022), Journal of medicinal chemistry

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.

Li D. et al, (2022), Commun Biol, 5

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Steadman D. et al, (2021), Journal of Medicinal Chemistry

Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status

Eyre DW. et al, (2021), Clinical Microbiology and Infection, 27, 1516.e7 - 1516.e14

Structural Insights into Notum Covalent Inhibition

Zhao Y. et al, (2021), Journal of Medicinal Chemistry, 64, 11354 - 11363

Notum deacylates octanoylated ghrelin

Zhao Y. et al, (2021), Molecular Metabolism, 49, 101201 - 101201

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Flanagan DJ. et al, (2021), Nature, 594, 430 - 435

Small-molecule inhibitors of carboxylesterase Notum

Zhao Y. et al, (2021), Future Medicinal Chemistry, 13, 1001 - 1015

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Schwerd T. et al, (2020), Bone Research, 8

Caffeine inhibits Notum activity by binding at the catalytic pocket

Zhao Y. et al, (2020), Communications Biology, 3

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

Zhao Y. et al, (2020), Nature Communications, 11

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.

Bochel AJ. et al, (2020), Structure (London, England : 1993), 28, 1300 - 1312.e5

The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs

Jackson V. et al, (2020)

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity

Mahy W. et al, (2020), Journal of Medicinal Chemistry, 63, 9464 - 9483

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

McGough IJ. et al, (2020), Nature, 585, 85 - 90

Structural basis of semaphorin‐plexin cis interaction

Rozbesky D. et al, (2020), The EMBO Journal, 39

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.

Schwerd T. et al, (2020), Bone research, 8

Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility

Rozbesky D. et al, (2020), Structure, 28, 507 - 515.e5

Cell guidance ligands, receptors and complexes - orchestrating signalling in time and space.

Rozbesky D. and Jones EY., (2020), Current opinion in structural biology, 61, 79 - 85

Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260

Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum

Zhao Y. et al, (2020), Journal of Pineal Research, 68

The guidance receptor plexin D1 is a mechanosensor in endothelial cells.

Mehta V. et al, (2020), Nature, 578, 290 - 295

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.

Atkinson BN. et al, (2020), Bioorganic & medicinal chemistry letters, 30

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Rozbesky D. et al, (2019), Nature Communications, 10

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

Barnkob MB. et al, (2019)

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Chen S. et al, (2019), Proceedings of the National Academy of Sciences, 116, 17470 - 17479

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

Atkinson BN. et al, (2019), MedChemComm, 10, 1361 - 1369

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

van der Klaauw AA. et al, (2019), Cell, 176, 729 - 742.e18

Designer protein delivers signal of choice

Jones EY., (2019), Nature, 565, 165 - 166

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Walters LC. et al, (2018), Nature Communications, 9

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins

Elegheert J. et al, (2018), Nature Protocols, 13, 2991 - 3017

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Walters LC. et al, (2018), Nature Communications, 9

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias

Gorvin CM. et al, (2018), Human Molecular Genetics, 27, 3720 - 3733

Structure of the Wnt signaling enhancer LYPD 6 and its interactions with the Wnt coreceptor LRP 6

Zhao Y. et al, (2018), FEBS Letters, 592, 3152 - 3162

Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function

Chavent M. et al, (2018), Structure, 26, 1025 - 1034.e2

Structural biology and the molecular mechanics of cell guidance signalling

Jones EY., (2018), FEBS OPEN BIO, 8, 57 - 57

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling

Gorvin CM. et al, (2018), Science Signaling, 11

A Calcium-Sensing Receptor (CASR) Mutation Causes Hypocalcemia by Disrupting a Transmembrane Salt Bridge that Modulates beta-arrestin Signaling.

Gorvin C. et al, (2017), JOURNAL OF BONE AND MINERAL RESEARCH, 32, S133 - S133

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

Schwerd T. et al, (2017), Journal of Experimental Medicine, 214, 2547 - 2562

Notum - an extracellular protein deacylase that suppresses Wnt signalling

Jones EY. et al, (2017), ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 73, C260 - C260

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Publications