Structural insights into Frizzled3 through nanobody modulators.
Hillier J. et al, (2024), Nat Commun, 15
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification
Pouwels KB. et al, (2024), Nature Communications, 15
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain
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Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
Barnkob MB. et al, (2024), Nat Commun, 15
Structure and function of Semaphorin-5A glycosaminoglycan interactions
Nagy GN. et al, (2024), Nature Communications, 15
Structural insights into Frizzled assembly by acylated Wnt and Frizzled Connector domain
Chang T-H. et al, (2022)
Structural Analysis and Development of Notum Fragment Screening Hits.
Zhao Y. et al, (2022), ACS chemical neuroscience
The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs.
Jackson V. et al, (2022), Structure (London, England : 1993)
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Willis NJ. et al, (2022), Journal of medicinal chemistry
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.
Li D. et al, (2022), Commun Biol, 5
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Steadman D. et al, (2021), Journal of Medicinal Chemistry
Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status
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Structural Insights into Notum Covalent Inhibition
Zhao Y. et al, (2021), Journal of Medicinal Chemistry, 64, 11354 - 11363
Notum deacylates octanoylated ghrelin
Zhao Y. et al, (2021), Molecular Metabolism, 49, 101201 - 101201
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Flanagan DJ. et al, (2021), Nature, 594, 430 - 435
Small-molecule inhibitors of carboxylesterase Notum
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A variant in IL6ST with a selective IL-11 signaling defect in human and mouse
Schwerd T. et al, (2020), Bone Research, 8
Caffeine inhibits Notum activity by binding at the catalytic pocket
Zhao Y. et al, (2020), Communications Biology, 3
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Zhao Y. et al, (2020), Nature Communications, 11
Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
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Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
Mahy W. et al, (2020), Journal of Medicinal Chemistry, 63, 9464 - 9483
Glypicans shield the Wnt lipid moiety to enable signalling at a distance.
McGough IJ. et al, (2020), Nature, 585, 85 - 90
Structural basis of semaphorin‐plexin cis interaction
Rozbesky D. et al, (2020), The EMBO Journal, 39
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.
Schwerd T. et al, (2020), Bone research, 8
Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility
Rozbesky D. et al, (2020), Structure, 28, 507 - 515.e5
Cell guidance ligands, receptors and complexes - orchestrating signalling in time and space.
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Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8
Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260
Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum
Zhao Y. et al, (2020), Journal of Pineal Research, 68
The guidance receptor plexin D1 is a mechanosensor in endothelial cells.
Mehta V. et al, (2020), Nature, 578, 290 - 295
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Atkinson BN. et al, (2020), Bioorganic & medicinal chemistry letters, 30
Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
Rozbesky D. et al, (2019), Nature Communications, 10
Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells
Barnkob MB. et al, (2019)
iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
Chen S. et al, (2019), Proceedings of the National Academy of Sciences, 116, 17470 - 17479
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Atkinson BN. et al, (2019), MedChemComm, 10, 1361 - 1369
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance
van der Klaauw AA. et al, (2019), Cell, 176, 729 - 742.e18
Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding
Walters LC. et al, (2018), Nature Communications, 9
Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins
Elegheert J. et al, (2018), Nature Protocols, 13, 2991 - 3017
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding
Walters LC. et al, (2018), Nature Communications, 9
Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias
Gorvin CM. et al, (2018), Human Molecular Genetics, 27, 3720 - 3733
Structure of the Wnt signaling enhancer LYPD 6 and its interactions with the Wnt coreceptor LRP 6
Zhao Y. et al, (2018), FEBS Letters, 592, 3152 - 3162
Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function
Chavent M. et al, (2018), Structure, 26, 1025 - 1034.e2
Structural biology and the molecular mechanics of cell guidance signalling
Jones EY., (2018), FEBS OPEN BIO, 8, 57 - 57
A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling
Gorvin CM. et al, (2018), Science Signaling, 11
A Calcium-Sensing Receptor (CASR) Mutation Causes Hypocalcemia by Disrupting a Transmembrane Salt Bridge that Modulates beta-arrestin Signaling.
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A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis
Schwerd T. et al, (2017), Journal of Experimental Medicine, 214, 2547 - 2562
Notum - an extracellular protein deacylase that suppresses Wnt signalling
Jones EY. et al, (2017), ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 73, C260 - C260