Innate immune signaling pathways: lessons from vaccinia virus
Hurst T., Bowie AG.
In recent years there has been an avalanche of new data revealing how the innate immune system, using pattern recognition receptors, initially senses viruses. This leads to signaling pathways resulting in transcription factor activation, and subsequent induction of cytokines and interferons. Here we show how studying the immune evasion strategies of vaccinia virus, and elucidating the underlying molecular mechanisms of these strategies, has provided some important lessons as to how these pathways operate and how they are subverted by viruses.