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Louise Sigfrid

Louise Sigfrid

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Aim: to study the prevalence, clinical management and outcomes of endemic arboviruses in Southeast Europe, focusing on West Nile Virus (WNV), tick-borne encephalitis virus (TBEV), Toscana virus (TOSV) and Crimean Congo haemorrhagic fever virus (CCHFV) (2016-2019).

Websites

Louise Sigfrid

MD, PhD, FFPH

Senior Clinical Research Fellow

  • International Severe Acute Respiratory and emerging Infection Consortium (ISARIC)
  • Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)

Work and Interests

  • Senior Clinical Research Fellow
  • Honorary Clinical Academic Public Health Consultant, UKHSA
  • Visiting Senior Lecturer Brighton & Sussex Medical School

Louise main focus is to strengthen preparedness for coordinated, effective research responses to epidemics and pandemics, to reduce morbidity and improve outcomes through clinical research, capacity strengthening and policy work. Further, with a focus and passion for reducing health inequalities and inequity in all aspects of work.

Louise research focus includes observational clinical, public health and social studies with a focus on new and (re-) emerging infections with epidemic potential, including acute respiratory infections (ARI), central nervous system (CNS), arbovirus and viral haemorrhagic fever (VHF) syndromes. She is managing a project exploring availability, inclusivity, scope and quality of clinical management guidelines (CMGs) for high consequence infectious diseases (HCIDs), and factors impacting on implementation of Chikungunya CMGs in Indonesia, and Ebola, Marburg and Covid-19 CMGs in Liberia, Sierra Leone and Uganda.

Louise is leading a team of systematic reviewers using different review methodologies, including rapid research needs appraisals and ‘living’ reviews, to generate evidence proactively and reactively in response to outbreaks to inform clinical and public health policies and research prioritisation.

She co-chairs the GloPID-R Clinical Trial Network & Funders (CTN&F) working group, bringing global research funders and CTNs together to address challenges to epidemic research responses globally.

As part of her work supporting ISARICs mission, Louise has developed harmonised, open-access clinical research tools for characterization of emerging infections, including Zika and COVID-19, and provides scientific and technical support to facilitate implementation in different resourced settings and leads collaborative analysis. Louise formed and co-chairs the ISARIC Global Covid-19 Follow Up working groups for adults and children, bringing international scientists, clinicians and patient group representatives together to characterise long term SARS-CoV-2 outcomes in different populations, with an aim to improve long term Covid-19 outcomes through research, engagement and advocacy.