Nick Provine
Career Development Fellow
I am a Career Development Fellow in the Pandemic Sciences Institute. I established his group in early 2023. The group’s research is focused on understanding the innate immune cells and signals that regulate the induction of immunity by vaccination, particularly in the context of viral vector vaccination. There is a specific focus on using functional multiomic and tissue sampling approaches, combined with in vitro and in vivo experimental models, to elucidate vaccine-induced innate cytokines that regulate cellular and humoral immunity.
Before coming to Oxford, I did my PhD training with Prof Dan Barouch at Harvard University examining how CD4+ T cells regulate adenovirus vector-induced immunity. I joined Prof. Paul Klenerman’s group at Oxford in 2016 for postdoctoral training. My postdoctoral work examined how cytokine-induced activation of innate-like T cells (MAIT cells and Vδ2+ γδT cells) promotes the immunogenicity of adenovirus vector vaccines, which revealed new insights into both the biology of unconventional T cells and this vaccine platform. The research group is continuing work in this area as one area of investigation.
In addition to research, I participate in the University's MSc in Integrated Immunology as a lecturer and course committee member.
Recent publications
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T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
Journal article
Ewer KJ. et al, (2021), Nature Medicine, 27, 270 - 278
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MAIT cell activation augments adenovirus vector vaccine immunogenicity
Journal article
Provine NM. et al, (2021), Science, 371, 521 - 526
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Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets
Journal article
FitzPatrick MEB. et al, (2021), Cell Reports, 34, 108661 - 108661
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Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.
Journal article
Buckland MS. et al, (2020), Nature communications, 11
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MAIT Cells in Health and Disease.
Journal article
Provine NM. and Klenerman P., (2020), Annual review of immunology, 38, 203 - 228
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Human MAIT Cell Activation In Vitro
Journal article
Hagel JP. et al, (2020), 97 - 124
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Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy
Journal article
Badamchi-Zadeh A. et al, (2018), The Journal of Immunology, 201, 2744 - 2752
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Memory inflation following adenoviral vaccination depends on IL-21
Journal article
Gordon CL. et al, (2018), Vaccine, 36, 7011 - 7016
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Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells
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Garner LC. et al, (2018), Frontiers in Immunology, 9
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Immunogenicity and Cross-Reactivity of Rhesus Adenoviral Vectors
Journal article
Iampietro MJ. et al, (2018), Journal of Virology, 92