Nick Provine
Wellcome Career Development Fellow
I am a Career Development Fellow in the Pandemic Sciences Institute. I established my group in early 2023. The group’s research is focused on understanding the innate immune cells and signals that regulate the induction of immunity by vaccination, particularly in the context of viral vector vaccination. There is a specific focus on using functional multiomic and tissue sampling approaches, combined with in vitro and in vivo experimental models, to elucidate vaccine-induced innate cytokines that regulate cellular and humoral immunity.
Before coming to Oxford, I did my PhD training with Prof Dan Barouch at Harvard University examining how CD4+ T cells regulate adenovirus vector-induced immunity. I joined Prof. Paul Klenerman’s group at Oxford in 2016 for postdoctoral training. My postdoctoral work examined how cytokine-induced activation of innate-like T cells (MAIT cells and Vδ2+ γδT cells) promotes the immunogenicity of adenovirus vector vaccines, which revealed new insights into both the biology of unconventional T cells and this vaccine platform. The research group is continuing work in this area as one area of investigation.
In addition to research, I participate in the University's MSc in Integrated Immunology course as a lecturer and course committee member.
Recent publications
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Dosing interval is a major factor determining the quality of T cells induced by SARS-CoV-2 mRNA and adenoviral vector vaccines
Journal article
Murray SM. et al, (2025), Science Immunology, 10
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MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines
Journal article
Amini A. et al, (2025), Science Immunology, 10
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Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1.
Journal article
Pudjohartono MF. et al, (2025), PLoS pathogens, 21
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Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
Journal article
FitzPatrick MEB. et al, (2025), Nature Immunology
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Distinct Requirements for CD4<sup>+</sup> T Cell Help for Immune Responses Induced by mRNA and Adenovirus-Vector SARS-CoV-2 Vaccines.
Journal article
Yong L. et al, (2024), European journal of immunology
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Multi‐site Ultrasound‐guided Fine Needle Aspiration to Study Cells and Soluble Factors From Human Lymph Nodes
Journal article
Al‐Diwani A. et al, (2024), Current Protocols, 4
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Single-cell integration reveals metaplasia in inflammatory gut diseases.
Journal article
Oliver AJ. et al, (2024), Nature, 635, 699 - 707
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Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes
Journal article
Al-Diwani A. et al, (2024), Brain
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Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1
Preprint
Pudjohartono MF. et al, (2024)
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Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial.
Journal article
Goodyear CS. et al, (2024), The Lancet. Rheumatology, 6, e339 - e351