Susan Morris
Dr
Senior Post-Doc Vaccine Development and Manufacturing
- Gilbert Group
Viral vector development and rapid manufacturing.
The main focus of my research is to generate Simian adenoviral vectored vaccines for a range of emerging and re-emerging pathogens including SARS CoV-2. Emerging pathogen outbreaks require a quick and efficient response. Manufacturing methods for Adenovirus vectors at large scale have been developed, however the process from selecting an antigen to starting a clinical trial can take at least 18 months. I have been working on improving the manufacturing processes for Adenovirus vaccines to minimise the time required from concept to end product. I am currently working on rapid analytical assays required during manufacturing. I work closely with the Clinical Biomanufacturing facility to ensure all processes are transferable to a GMP environment.
Another aspect of my research is the design and development of new viral vectors for various emerging pathogens. I am also interested in exploring novel vaccine delivery mechanisms.
Recent publications
Rational Design of a Chimpanzee Adenoviral-Vector Vaccine Against Yellow Fever Through the Modification of Antigen Transmembrane Domains
Journal article
Ulaszewska M. et al, (2026), Vaccines, 14, 273 - 273
Development and Evaluation of Compact Semi-Synthetic Promoters for Enhanced Antigen Expression in Adenoviral-Vectored Vaccines
Journal article
Hlaváč M. et al, (2026), Vaccines, 14, 260 - 260
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms.
Journal article
Bissett C. et al, (2026), The Journal of experimental medicine, 223
Simian Adenoviruses As Vaccine Vectors
Journal article
Morris SJ. et al, (2016), Future Virology, 11, 649 - 659
Laboratory-Scale Production of Replication-Deficient Adenovirus Vectored Vaccines
Chapter
Morris SJ. et al, (2016), 121 - 135