Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Members of four cell guidance molecule families (the netrins, slits, ephrins and semaphorins) interact with their cognate cell surface receptors to guide cells during development and maintain tissue homeostasis. Integrated structure and cell-based analyses are providing insight into the mechanisms by which these signalling systems can deliver myriad outcomes that require exquisite accuracy in timing and location. Here we review recent advances in our understanding of the roles of oligomeric states, auto-inhibition, signalling assembly size and composition in cell guidance cue function.

Original publication

DOI

10.1016/j.sbi.2019.11.007

Type

Journal article

Journal

Current opinion in structural biology

Publication Date

04/2020

Volume

61

Pages

79 - 85

Addresses

Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.

Keywords

Animals, Humans, Macromolecular Substances, Ephrins, Cell Adhesion Molecules, Semaphorins, Receptors, Cell Surface, Nerve Tissue Proteins, Ligands, Signal Transduction, Protein Binding, Protein Interaction Domains and Motifs, Protein Multimerization, Biomarkers