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Norovirus is a leading cause of epidemic acute gastroenteritis. More than 30 genotypes circulate in humans, some are common, and others are only sporadically detected. Here, we investigated whether serology can be used to determine which genotypes infect children. We established a multiplex protein microarray with structural and non-structural norovirus antigens that allowed simultaneous antibody testing against 30 human GI and GII genotypes. Antibody responses of sera obtained from 287 children aged 

Original publication




Journal article


Scientific reports

Publication Date





Department of Viroscience, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.


Humans, Norovirus, Caliciviridae Infections, Gastroenteritis, Capsid Proteins, Phylogeny, Genotype, Child, Preschool, Infant, Europe, Immunity, Humoral