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BackgroundIndividuals with comorbidities are at increased risk of severe respiratory syncytial virus (RSV) infection. We estimated RSV-associated respiratory hospitalization among adults aged ≥45 years with comorbidities in Denmark and Scotland.MethodsBy analyzing national hospital and virologic data, we estimated annual RSV-associated hospitalizations by 7 selected comorbidities and ages between 2010 and 2018. We estimated rate ratios of RSV-associated hospitalization for adults with comorbidity than the overall population.ResultsIn Denmark, annual RSV-associated hospitalization rates per 1000 adults ranged from 3.1 for asthma to 19.4 for chronic kidney disease (CKD). In Scotland, rates ranged from 2.4 for chronic liver disease to 9.0 for chronic obstructive pulmonary disease (COPD). In both countries, we found a 2- to 4-fold increased risk of RSV hospitalization for adults with COPD, ischemic heart disease, stroke, and diabetes; a 1.5- to 3-fold increased risk for asthma; and a 3- to 7-fold increased risk for CKD. RSV hospitalization rates among adults aged 45 to 64 years with COPD, asthma, ischemic heart disease, or CKD were higher than the overall population.ConclusionsThis study provides important evidence for identifying risk groups and assisting health authorities in RSV vaccination policy making.

Original publication




Journal article


The Journal of infectious diseases

Publication Date





S70 - S77


Centre for Global Health, Usher Institute, University of Edinburgh, United Kingdom.


Humans, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, Asthma, Pulmonary Disease, Chronic Obstructive, Myocardial Ischemia, Hospitalization, Comorbidity, Adult, Renal Insufficiency, Chronic