Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4 + T cell responses that impair CD8 + T cell function
Larocca RA., Provine NM., Aid M., Iampietro MJ., Borducchi EN., Badamchi-Zadeh A., Abbink P., Ng’ang’a D., Bricault CA., Blass E., Penaloza-MacMaster P., Stephenson KE., Barouch DH.
Negative immunologic regulatory pathways of vaccine vectors suppress antigen-specific CD8 + T cell responses.