Mahan Ghafari
Postdoctoral Research Scientist
I am mainly interested in understanding the evolutionary and epidemiological processes involved in determining the rate at which viruses evolve over time. In my current postdoctoral work, I study the within-host evolutionary dynamics, and transmission, of chronic viral infections such as SARS-CoV-2 and HIV. My focus is on analysing whole genome sequencing data to better understand the within-host evolution and transmission of these viruses, including the roles of selection, recombination, and compartmentalisation.
Recent publications
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Genetically distinct within-host subpopulations of hepatitis C virus persist after Direct-Acting Antiviral treatment failure
Journal article
Zhao L. et al, (2025), PLOS Pathogens, 21, e1012959 - e1012959
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Lineage-aware evolutionary analysis of hepatitis C virus within-host dynamics
Preprint
Zhao L. et al, (2024)
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Determinants of SARS-CoV-2 within-host evolutionary rates in persistently infected individuals
Preprint
Ghafari M. et al, (2024)
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Revisiting the origins of the Sobemovirus genus: A case for ancient origins of plant viruses.
Journal article
Ghafari M. et al, (2024), PLoS Pathog, 20
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Biased estimates of phylogenetic branch lengths resulting from the discretised Gamma model of site rate heterogeneity
Preprint
Ferretti L. et al, (2024)